呼吸道疾病

呼吸道疾病是涉及從鼻腔到肺部的呼吸系統(tǒng)的多種疾病群。常見的類型包括感冒和流感（由病毒引起）、支氣管炎（支氣管的炎癥）、哮喘（慢性炎癥性肺?。?、慢性阻塞性肺病（COPD，包括慢性支氣管炎和肺氣腫）、肺炎（肺部感染）、肺結核（由結核桿菌引起的傳染性疾病）以及肺癌（肺部惡性腫瘤）。這些疾病可能由病毒、細菌、過敏原、污染物、吸煙和其他環(huán)境因素引起。

目前，針對呼吸道疾病的藥物開發(fā)主要集中在以下幾個方面：

炎癥介質：即抗炎藥物，目的是減少哮喘和COPD等炎癥性肺病的癥狀。同時，針對特定炎癥介質的生物制劑正在開發(fā)，如抗IL-5和抗IL-13，用于治療嚴重的哮喘。
抗菌藥物：針對耐藥性細菌的新型抗菌藥物對于治療肺炎等呼吸道感染至關重要。
免疫檢查點：如PD-1/PD-L1抑制劑等免疫療法，用于治療肺癌。
基因治療：針對遺傳性呼吸系統(tǒng)疾病，如囊性纖維化的基因治療正在研究中。
腫瘤標志物：靶向治療，如EGFR抑制劑，正在非小細胞肺癌的治療中發(fā)揮作用。
疫苗：流感疫苗和肺炎球菌疫苗等針對呼吸道疾病的疫苗不斷更新以適應病原體的變異。

呼吸道疾病藥物靶點

呼吸道疾病靶點相關產品推薦

● 靶點蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

ACE2
CSB-MP866317HU

SARS-CoV-2 Spike protein RBD his/sumostar tag (CSB-YP3324GMY1) captured on COOH chip can bind Human ACE2 protein Fc tag (CSB-MP866317HU) with an affinity constant of 100 nM as detected by LSPR Assay.

TACSTD2(TROP2)
CSB-MP023072HU1

Measured in cell activity assay using U937 cells, the EC₅₀ for this effect is 190.2-298.6 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

IL4R
CSB-MP011661HU2-B

Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC₅₀ is 12.68-14.23 ng/mL.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

產品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-AP005671HU	ACE2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial, Biotinylated (Active)	CSB-MP866317HU-B	ACE2	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP866317HU	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Macaca fascicularis Angiotensin-converting enzyme (ACE2), partial (Active)	CSB-MP3414MOV	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Paguma larvata Angiotensin-converting enzyme 2 (ACE2), partial (Active)	CSB-MP684964PAL	ACE2	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Basigin (BSG), partial (Active)	CSB-MP002831HU1	BSG	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	CD86	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active)	CSB-MP005508HU(A4)	CLDN6	Mammalian cell	C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active)	CSB-MP005508HU(A4)f4	CLDN6	Mammalian cell	C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged

● 穩(wěn)定細胞株

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

HEK293F/Human DLL3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

產品名稱	貨號	靶點	反應種屬	應用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD27 Recombinant Monoclonal Antibody	CSB-RA953976A0HU	CD27	Human	ELISA, WB
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD86 Recombinant Monoclonal Antibody	CSB-RA004965A0HU	CD86	Human	ELISA, WB
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
DLL3 Recombinant Monoclonal Antibody	CSB-RA882142A1HU	DLL3	Human	ELISA, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ELANE Recombinant Monoclonal Antibody	CSB-RA200985A0HU	ELANE	Human	ELISA, IHC, FC

● ELISA試劑盒

產品名稱	貨號	靶點	檢測范圍	靈敏度
Rat Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E14308r	ACE2	0.02 ng/ml - 20 ng/ml	0.02 ng/ml
Human Angiotensin converting enzyme 2, ACE2 ELISA Kit	CSB-E04489h	ACE2	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse Angiotensin converting enzyme 2(ACE2)ELISA Kit	CSB-E17204m	ACE2	6.25 pg/mL-400 pg/mL	1.56 pg/mL
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Bovine Angiopoietin-1(ANGPT1) ELISA kit	CSB-EL001706BO	ANGPT1	12.5 ng/mL-800 ng/mL	1.384 ng/mL
Human Angiopoietin-1(ANGPT1) ELISA kit	CSB-EL001706HU	ANGPT1	1.25 ng/mL-80 ng/mL	0.091 ng/mL
Mouse Angiopoietin 1,ANG-1 ELISA Kit	CSB-E07302m	ANGPT1	1.25 ng/mL-80 ng/mL	0.312 ng/mL
Rat Angiopoietin 1,ANG-1 ELISA Kit	CSB-E07303r	ANGPT1	6.25 ng/mL-400 ng/mL	1.56 ng/mL
Pig Angiopoietin 1,ANG-1 ELISA Kit	CSB-E08457p	ANGPT1	6 ng/mL-200 ng/mL	6 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit	CSB-EL002476HU	AXL	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit	CSB-EL002476MO	AXL	31.25 pg/ml-2000 pg/ml	7.81 pg/ml
Human Cluster of differentiation 147,CD147 Elisa Kit	CSB-E12994h	BSG	12.5 pg/mL-800 pg/mL	3.12 pg/mL