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肝癌

肝癌是一種發(fā)生在肝臟的惡性腫瘤,主要包括肝細胞癌(Hepatocellular carcinoma, HCC)、肝內膽管癌(Intrahepatic cholangiocarcinoma, ICC)和混合型肝細胞癌-膽管癌(Combined hepatocellular-cholangiocarcinoma, cHCC-CCA)等類型。

肝癌的發(fā)病原因多樣,常見的風險因素包括乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染、過度飲酒、非酒精性脂肪性肝炎、肝硬化以及其他原因引起的慢性肝病。肝癌的早期癥狀較為隱匿,但隨著病情進展,可能出現(xiàn)腹痛、腹部腫脹、黃疸、體重下降等癥狀。

肝癌常用的治療手段包括手術切除、肝移植、局部消融治療、經動脈化療栓塞(Transarterial chemoembolization, TACE)、放射治療、系統(tǒng)抗腫瘤治療等。近年來,隨著對肝癌生物學認識的深入和治療技術的進步,肝癌的藥物研發(fā)也取得了顯著進展,如:

  • 分子靶向治療:多納非尼(Sorafenib)、侖伐替尼(Lenvatinib)等多激酶抑制劑在肝癌治療中顯示出較好的療效,能夠抑制腫瘤生長和血管生成。
  • 免疫治療:免疫檢查點抑制劑如納武利尤單抗(Nivolumab)和帕博利珠單抗(Pembrolizumab)等已在肝癌治療中顯示出潛力,通過激活患者自身的免疫系統(tǒng)來攻擊腫瘤細胞。
  • 聯(lián)合治療:將免疫治療藥物與血管生成抑制劑或其他藥物聯(lián)合使用,如阿特珠單抗(Atezolizumab)與貝伐珠單抗(Bevacizumab)的聯(lián)合治療,已被證實能顯著延長患者的生存期。

肝癌藥物靶點相關產品推薦

● 靶點蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP009705HU(M) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC50 is 4.739-7.092 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP675446HU Activity Verified

HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.

CSB-MP013714HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.

CSB-MP007765HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.

產品名稱 貨號 靶點 來源 蛋白標簽
Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active) CSB-BP001262HU1 ACVRL1 Baculovirus C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) CSB-AP003871HU FGFR3 Mammalian cell C-terminal Fc-tagged
Recombinant Human Glypican-3 (GPC3), partial (Active) CSB-AP005371HU GPC3 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Glypican-3 (GPC3) (G537R), partial (Active) CSB-MP009705HU(M) GPC3 Mammalian cell N-terminal 6xHis-Myc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005281HU HAVCR2 Mammalian cell C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005291HU HAVCR2 Mammalian cell C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active) CSB-AP005341MO Havcr2 Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-15 protein (IL15) (Active) CSB-AP001621HU IL15 E.Coli Tag-Free
Recombinant Human Interleukin-15 (IL15) (Active) CSB-AP004391HU IL15 E.coli Tag-Free

● 穩(wěn)定細胞株

CSB-SC009705HU2 FACS

CT26/Human GPC3 Stable Cell Line

CSB-SC009705HU2

Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2μg/1*106 cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU
CSB-RA792129A0HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

TP53 Recombinant Monoclonal Antibody
CSB-RA024077MA1HU
CSB-RA024077MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA024077MA1HU (red line) at 1:100.

產品名稱 貨號 靶點 反應種屬 應用范圍
ACVRL1 Recombinant Monoclonal Antibody CSB-RA555022A0HU ACVRL1 Human ELISA, WB, IHC
ACVRL1 Recombinant Monoclonal Antibody CSB-RA001262MA1HU ACVRL1 Human ELISA
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody CSB-RA932207A0HU EPCAM Human ELISA, WB
EPCAM Recombinant Monoclonal Antibody CSB-RA439934A0HU EPCAM Human ELISA, WB, IHC
EPCAM Recombinant Monoclonal Antibody CSB-RA007717MA1HU EPCAM Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA

● ELISA試劑盒

產品名稱 貨號 靶點 檢測范圍 靈敏度
Human Alpha-fetoprotein,AFP ELISA Kit CSB-E04770h AFP 1.563 ng/mL-100 ng/mL 1.332 ng/mL
Mouse Alpha-fetoprotein,AFP ELISA Kit CSB-E08282m AFP 1.23 ng/ml-900 ng/ml. 1.23 ng/ml.
Rat Alpha-fetoprotein,AFP ELISA Kit CSB-E08281r AFP 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Pig Alpha-fetoprotein(AFP) ELISA kit CSB-EL001421PI AFP 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Mouse Protein delta homolog 1(DLK1) ELISA kit CSB-EL006945MO DLK1 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit CSB-EL007717HU EPCAM 0.625 ng/ml-40 ng/ml 0.156 ng/ml
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit CSB-EL008646HU FGFR3 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Glypican-3,GPC-3 ELISA Kit CSB-E11333h GPC3 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Glypican-3(GPC-3)ELISA Kit CSB-E15877m GPC3 3.12 ng/mL-200 ng/mL 0.78 ng/mL