胃癌
胃癌是起源于胃黏膜上皮細(xì)胞的惡性腫瘤,它是全球癌癥死亡率較高的癌癥之一。胃癌的發(fā)展可能與多種因素有關(guān),包括遺傳、不良飲食習(xí)慣、吸煙、酗酒、幽門螺桿菌感染等。根據(jù)腫瘤的生物學(xué)特征,胃癌也可以分為不同的亞型,如腸型、彌漫型和混合型等。
胃癌的治療通常包括手術(shù)切除、化療、放療和靶向治療等方法。近年來,胃癌的藥物研發(fā)取得了顯著進(jìn)展,特別是在靶向治療和免疫治療領(lǐng)域。
- 靶向治療藥物主要針對(duì)胃癌細(xì)胞的特定分子靶點(diǎn),如HER2、VEGFR、EGFR等。例如,對(duì)于HER2陽性的胃癌,曲妥珠單抗(Trastuzumab)是一種有效的治療藥物。此外,針對(duì)VEGFR和EGFR的小分子酪氨酸激酶抑制劑,如阿法替尼(Afatinib)和雷格拉替尼(Regorafenib),也在胃癌治療中顯示出一定的療效。
- 免疫治療是胃癌治療領(lǐng)域的新興方向,它通過激活患者自身的免疫系統(tǒng)來攻擊癌細(xì)胞。免疫檢查點(diǎn)抑制劑,如PD-1抑制劑帕博利珠單抗(Pembrolizumab)和CTLA-4抑制劑伊皮利莫單抗(Ipilimumab),已經(jīng)在一些胃癌患者中顯示出治療潛力。這些藥物通過解除腫瘤對(duì)免疫系統(tǒng)的抑制,增強(qiáng)免疫系統(tǒng)對(duì)癌細(xì)胞的攻擊。
胃癌藥物靶點(diǎn)
胃癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP005498HU(A5)
-AC1.jpg)
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.
CSB-MP023997HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL
● 穩(wěn)定細(xì)胞株

CT26/Human ROR1 Stable Cell Line
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

HEK293T/Human CDH17 Stable Cell Line
Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重組抗體
CSB-RA613267MA1HU

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*106 cells).
CSB-RA010053A3HU

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106 cells)。
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA792129A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD55 Recombinant Monoclonal Antibody | CSB-RA440943A0HU | CD55 | Human | ELISA, WB, IHC |
CDH17 Recombinant Monoclonal Antibody | CSB-RA613267MA1HU | CDH17 | Human | ELISA,F(xiàn)C |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
CLDN18 Recombinant Monoclonal Antibody | CSB-RA005498A2HU | CLDN18 | Human | ELISA, FC |
Claudin-18.2 Recombinant Monoclonal Antibody | CSB-RA005498A1HU | CLDN18 | Human | ELISA, FC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
EPCAM Recombinant Monoclonal Antibody | CSB-RA932207A0HU | EPCAM | Human | ELISA, WB |
EPCAM Recombinant Monoclonal Antibody | CSB-RA439934A0HU | EPCAM | Human | ELISA, WB, IHC |