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胃癌

胃癌是起源于胃黏膜上皮細(xì)胞的惡性腫瘤,它是全球癌癥死亡率較高的癌癥之一。胃癌的發(fā)展可能與多種因素有關(guān),包括遺傳、不良飲食習(xí)慣、吸煙、酗酒、幽門螺桿菌感染等。根據(jù)腫瘤的生物學(xué)特征,胃癌也可以分為不同的亞型,如腸型、彌漫型和混合型等。

胃癌的治療通常包括手術(shù)切除、化療、放療和靶向治療等方法。近年來,胃癌的藥物研發(fā)取得了顯著進(jìn)展,特別是在靶向治療和免疫治療領(lǐng)域。

  • 靶向治療藥物主要針對(duì)胃癌細(xì)胞的特定分子靶點(diǎn),如HER2、VEGFR、EGFR等。例如,對(duì)于HER2陽性的胃癌,曲妥珠單抗(Trastuzumab)是一種有效的治療藥物。此外,針對(duì)VEGFR和EGFR的小分子酪氨酸激酶抑制劑,如阿法替尼(Afatinib)和雷格拉替尼(Regorafenib),也在胃癌治療中顯示出一定的療效。
  • 免疫治療是胃癌治療領(lǐng)域的新興方向,它通過激活患者自身的免疫系統(tǒng)來攻擊癌細(xì)胞。免疫檢查點(diǎn)抑制劑,如PD-1抑制劑帕博利珠單抗(Pembrolizumab)和CTLA-4抑制劑伊皮利莫單抗(Ipilimumab),已經(jīng)在一些胃癌患者中顯示出治療潛力。這些藥物通過解除腫瘤對(duì)免疫系統(tǒng)的抑制,增強(qiáng)免疫系統(tǒng)對(duì)癌細(xì)胞的攻擊。

胃癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP005498HU(A5) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP013714HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Cadherin-17 (CDH17), partial (Active) CSB-MP613267HU CDH17 Mammalian cell C-terminal?10xHis-tagged
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) CSB-MP4664MOV CDH17 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) CSB-MP4304MOV CLDN18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) CSB-MP005498MO(F3) Cldn18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) CSB-AP003871HU FGFR3 Mammalian cell C-terminal Fc-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) CSB-MP010053HU GUCY2C Mammalian cell N-terminal 10xHis-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC020067HU
CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC613267HU2
CSB-SC613267HU2 FACS

HEK293T/Human CDH17 Stable Cell Line

Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CDH17 Recombinant Monoclonal Antibody
CSB-RA613267MA1HU
CSB-RA613267MA1HU FC

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*106 cells).

GUCY2C Recombinant Monoclonal Antibody
CSB-RA010053A3HU
CSB-RA010053A3HU FC

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106 cells)。

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU
CSB-RA792129A0HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD55 Recombinant Monoclonal Antibody CSB-RA440943A0HU CD55 Human ELISA, WB, IHC
CDH17 Recombinant Monoclonal Antibody CSB-RA613267MA1HU CDH17 Human ELISA,F(xiàn)C
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CLDN18 Recombinant Monoclonal Antibody CSB-RA005498A2HU CLDN18 Human ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody CSB-RA005498A1HU CLDN18 Human ELISA, FC
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody CSB-RA932207A0HU EPCAM Human ELISA, WB
EPCAM Recombinant Monoclonal Antibody CSB-RA439934A0HU EPCAM Human ELISA, WB, IHC

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human decay-accelerating factor(DAF/CD55)ELISA Kit CSB-E05121h CD55 0.39 ng/ml- 25ng/ml 0.09 ng/ml
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit CSB-EL007717HU EPCAM 0.625 ng/ml-40 ng/ml 0.156 ng/ml
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit CSB-EL008646HU FGFR3 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Hepatitis A virus cellular receptor 2(HAVCR2) ELISA kit CSB-EL010145HU HAVCR2 47 pg/mL-3000 pg/mL 11.75 pg/mL
Human intercellular adhesion molecule 1,ICAM-1 ELISA Kit CSB-E04574h ICAM1 0.78 ng/mL-50 ng/mL 0.195 ng/mL
Mouse intercellular adhesion molecule 1,ICAM-1 ELISA KIT CSB-E04575m ICAM1 78 ng/mL-5000 ng/mL 19.5 ng/mL
Rat intercellular adhesion molecule 1,ICAM-1 ELISA Kit CSB-E04576r ICAM1 78.125 pg/mL-5000 pg/mL 24.321 pg/mL