免疫類疾病(免疫紊亂)
免疫系統(tǒng)是人體抵御外來病原體、維持內(nèi)部穩(wěn)定的重要系統(tǒng)。免疫紊亂是指人體免疫系統(tǒng)功能失調(diào)的狀態(tài),這種失調(diào)可能是由于遺傳、環(huán)境、生活方式等多種因素引起的,可能會導(dǎo)致多種疾病。免疫紊亂可以分為兩大類:免疫缺陷和自身免疫疾病。
- 免疫缺陷:是指免疫系統(tǒng)功能低下,無法有效抵御外來病原體的侵害。免疫缺陷可能是先天性的,如先天性免疫缺陷?。灰部赡苁呛筇煨缘?,如艾滋病、長期使用免疫抑制劑等。免疫缺陷會導(dǎo)致患者容易感染、疾病恢復(fù)緩慢等問題。
- 自身免疫疾?。?/b>是指免疫系統(tǒng)錯(cuò)誤地攻擊自身組織,導(dǎo)致組織損傷和功能障礙。常見的自身免疫疾病包括類風(fēng)濕關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡、甲狀腺疾病等。
免疫缺陷和自身免疫疾病是兩類重要的免疫相關(guān)疾病,近年來在藥物研發(fā)方面取得了顯著進(jìn)展:
- 針對免疫缺陷的藥物研發(fā):leniolisib是一種口服選擇性磷脂酰肌醇3-激酶δ(PI3Kδ)抑制劑,已被美國食品和藥物管理局(FDA)受理進(jìn)行優(yōu)先審查,用于治療活化的肌醇磷脂3-激酶δ綜合征(APDS),這是一種罕見的原發(fā)性免疫缺陷病。這表明針對特定免疫缺陷病的精準(zhǔn)治療策略正在逐步實(shí)現(xiàn)。
- 針對自身免疫疾病的藥物研發(fā):自身免疫性疾病的治療藥物包括傳統(tǒng)的合成抗風(fēng)濕藥(DMARDs),如激素、免疫抑制劑、免疫調(diào)節(jié)劑和抗炎藥物。近年來,生物制劑和靶向DMARDs的研發(fā)取得了顯著進(jìn)展,例如大分子單克隆抗體(如英夫利昔單抗、托珠單抗)和JAK抑制劑(如托法替尼、巴瑞特尼)。
此外,細(xì)胞因子類藥物通過調(diào)節(jié)免疫反應(yīng)在治療免疫缺陷和自身免疫疾病中具有重要作用。例如,通過PEG化增加IL-2半衰期的藥物NKTR-214,以及通過融合技術(shù)增加細(xì)胞因子靶向特異性的藥物,如ALT-803(IL-15“超級激動劑”復(fù)合物)??贵w融合細(xì)胞因子,如IL-2、TNF、IL-15等,通過特定的抗體導(dǎo)向技術(shù),將細(xì)胞因子定向輸送到疾病部位,以提高治療效果和減少副作用。
免疫類疾病藥物靶點(diǎn)
- ALB
- APP
- ASN1
- asnA
- BTLA
- C1R
- C1S
- C3
- C5
- CCR5
- CCR7
- CD19
- CD2
- CD200R1
- CD22
- CD247
- CD274
- CD28
- CD33
- CD34
- CD37
- CD38
- CD3E
- CD4
- CD40
- CD40LG
- CD44
- CD47
- CD52
- CD6
- CD7
- CD70
- CD79B
- CD80
- CD86
- CSF1R
- CSF2
- CSF2RA
- CSF3R
- CTLA4
- CXCL13
- CXCR4
- CXCR5
- DNA2
- DRD4
- EGFR
- EpoR
- ERBB2
- FCER1A
- FCER2
- FCGR1A
- FCGR2B
- FCGR3A
- FCGRT
- FN1
- GCGR
- GHR
- GLP1R
- GP41
- GPRC5D
- HAVCR2
- HLA-DRA
- ICAM1
- ICOS
- IFNAR1
- IFNAR1
- IFNB1
- IFNGR1
- IGF1R
- IL10RA
- IL12A
- IL12RB1
- IL13
- IL15
- IL15RA
- IL17A
- IL17F
- IL18
- IL1A
- IL1B
- IL1R1
- IL1RL1
- IL2
- IL21
- IL22RA1
- IL23A
- IL25
- IL2RA
- IL2RA
- IL2RB
- IL2RG
- IL31
- IL33
- IL3RA
- IL3RA
- IL4
- IL4R
- IL5
- IL5RA
- IL6
- IL6R
- IL6ST
- IL7R
- INSR
- ITGA4
- ITGA4
- ITGAL
- KIT
- KLKB1
- LAG3
- MASP2
- MET
- MPL
- MS4A1
- NCR1
- NT5E
- PDCD1
- RHD
- ROR1
- SDC1
- SIRPA
- SLAMF7
- SLC25A21
- SNAP25
- TGFB1
- TIGIT
- TLR3
- TNF
- TNFRSF10B
- TNFRSF13C
- TNFRSF17
- TNFRSF1A
- TNFRSF1B
- TNFRSF4
- TNFRSF8
- TNFSF11
- TNFSF13
- TNFSF13B
- TNFSF4
- TNFSF9
- TOP1
- TSLP
- VEGFA
免疫類疾病藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml
● 穩(wěn)定細(xì)胞株

CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重組抗體
CSB-RA303909A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50.
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA919940A0HU

Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.
CSB-RA983271A0HU

Overlay histogram showing Hela cells stained with CSB-RA983271A0HU (red line) at 1:50.
產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
BTLA Recombinant Monoclonal Antibody | CSB-RA773799MA1HU | BTLA | Human | ELISA, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA303909A0HU | C3 | Human | ELISA, WB, IHC, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA699863A0HU | C3 | Human | ELISA, IHC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD22 Recombinant Monoclonal Antibody | CSB-RA962691A0HU | CD22 | Human | ELISA, IHC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD34 Recombinant Monoclonal Antibody | CSB-RA004926A0HU | CD34 | Human | ELISA, IHC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938A0HU | CD44 | Human | ELISA, WB, IHC |
CD44 Recombinant Monoclonal Antibody | CSB-RA292372A0HU | CD44 | Human | ELISA, WB, IHC, IF, FC |
● ELISA試劑盒
產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 檢測范圍 | 靈敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868HU | BTLA | 0.45 ng/mL-30 ng/mL | 0.11 ng/mL |
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868MO | BTLA | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Human Complement 3,C3 ELISA Kit | CSB-E08665h | C3 | 4.7 ng/mL-300 ng/mL | 4.031 ng/mL |
Pig Complement 3,C3 ELISA Kit | CSB-E06920p | C3 | 0.625 μg/mL-10 μg/mL | 0.625 μg/mL |
Rat Complement 3,C3 ELISA Kit | CSB-E08666r | C3 | 0.625 μg/mL-40 μg/mL | 0.156 μg/mL |
Mouse Complement 3,C3 ELISA Kit | CSB-E08667m | C3 | 93.75 ng/mL-6000 ng/mL | 23.44 ng/mL |
Rabbit Complement 3,C3 ELISA Kit | CSB-E08668Rb | C3 | 27.3 ng/mL-7000 ng/mL | 27.3 ng/mL |
Fish Complement 3,C3 ELISA Kit | CSB-E09727s | C3 | 12.5 μg/mL-500 μg/mL | 12.5 μg/mL |
Monkey Complement 3(C3)ELISA Kit | CSB-E16528Mk | C3 | 4.68 ng/mL-300 ng/mL | 1.17 ng/mL |